Insulin transiently increases tau phosphorylation : Involvement of glycogen synthase kinase-3β and Fyn tyrosine kinase

Abstract : The modulation of tau phosphorylation in response to insulin was examined in human neuroblastoma SH‐SY5Y cells. Insulin treatment resulted in a transient increase in tau phosphorylation followed by a decrease in tau phosphorylation that correlated directly with a sequential activation and deactivation of glycogen synthese kinase‐3β (GSK‐3β). The insulin‐induced increase in tau phosphorylation and concurrent activation of GSK‐3β was rapid (