Professional Antigen-Presentation Function by Human gamma delta T Cells

Human gamma delta T cells are considered to play a vital role in protective immunity through cytokine secretion and cytotoxic activity. We report that cells expressing the V gamma 2V delta 2 super(+)-T cell receptor (V delta 2 super(+) T cells) also display principal characteristics of professional antigen-presenting cells such as dendritic cells. Thus, when activated, these cells efficiently processed and displayed antigens and provided co-stimulatory signals sufficient for strong induction of naive alpha beta T cell proliferation and differentiation. We suggest that, upon microbial activation, V delta 2 super(+) T cells participate in the induction of adaptive immune responses and that these cells may be a useful tool in vaccine development and immunotherapy.