Antidepressant-like effect of bright light is potentiated by l -serine administration in a mouse model of seasonal affective disorder

Highlights • Bright light reduced depression-like behavior in mice exposed to short-day condition. • Effect of light on depression-like behavior was potentiated by l -serine injection. • Serotonin signals in the raphe nuclei were enhanced by bright light and l -serine. • Bright light may elicit an a...

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Veröffentlicht in:	Brain research bulletin 2015-09, Vol.118, p.25-33
Hauptverfasser:	Kawai, Misato, Goda, Ryosei, Otsuka, Tsuyoshi, Iwamoto, Ayaka, Uotsu, Nobuo, Furuse, Mitsuhiro, Yasuo, Shinobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology Behavior, Animal - drug effects Brain - drug effects c-Fos Depression-like behavior Disease Models, Animal Fluoxetine - pharmacology Light Male Mice Mice, Inbred C57BL Mouse Neurology Phototherapy - methods Random Allocation Raphe nuclei Seasonal affective disorder Seasonal Affective Disorder - drug therapy Seasonal Affective Disorder - metabolism Seasonal Affective Disorder - therapy Serine - pharmacology Serotonin Serotonin - metabolism Serotonin Uptake Inhibitors - pharmacology
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Zusammenfassung:	Highlights • Bright light reduced depression-like behavior in mice exposed to short-day condition. • Effect of light on depression-like behavior was potentiated by l -serine injection. • Serotonin signals in the raphe nuclei were enhanced by bright light and l -serine. • Bright light may elicit an antidepressant-like effect via enhanced serotonin signals.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2015.08.010