Identification of intellectual disability genes showing circadian clock-dependent expression in the mouse hippocampus

Highlights • Identification of 663 circadian clock controlled genes in the hippocampus. • Inter-regulation of circadian clock controlled gene expression in the hippocampus. • Expression of intellectual disability genes is not preferentially controlled by circadian clock. • Identification of 30 intel...

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Veröffentlicht in:	Neuroscience 2015-11, Vol.308, p.11-50
Hauptverfasser:	Renaud, J, Dumont, F, Khelfaoui, M, Foisset, S.R, Letourneur, F, Bienvenu, T, Khwaja, O, Dorseuil, O, Billuart, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western circadian clock Circadian Clocks - genetics Circadian Clocks - physiology Gene Expression - physiology hippocampus Hippocampus - metabolism intellectual disability Intellectual Disability - genetics Intellectual Disability - metabolism Male memory Mice, Inbred C57BL Microarray Analysis Neurology Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction sleep
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Zusammenfassung:	Highlights • Identification of 663 circadian clock controlled genes in the hippocampus. • Inter-regulation of circadian clock controlled gene expression in the hippocampus. • Expression of intellectual disability genes is not preferentially controlled by circadian clock. • Identification of 30 intellectual disability genes transcriptionally controlled by circadian clock.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.08.066