IL-17A Has Some Nerve

Sensory neurons are important in controlling cutaneous inflammation, but the role of neurons in host antimicrobial defense was relatively unknown. Kaplan and colleagues now demonstrate that nociceptive fibers within the dermis play a crucial role in antifungal defenses through their influence on der...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2015-09, Vol.43 (3), p.414-415
Hauptverfasser:	Sanford, James A., Gallo, Richard L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Bacterial infections Dendritic Cells - immunology Immune system Immunity - immunology Inflammation Interleukin-23 - immunology Lymphocytes Nervous system Neurons Neuropeptides Psoriasis Sensory Receptor Cells - immunology Skin Skin - immunology Staphylococcus infections
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Sensory neurons are important in controlling cutaneous inflammation, but the role of neurons in host antimicrobial defense was relatively unknown. Kaplan and colleagues now demonstrate that nociceptive fibers within the dermis play a crucial role in antifungal defenses through their influence on dermal dendritic cells and induction of IL-17A. Sensory neurons are important in controlling cutaneous inflammation, but the role of neurons in host antimicrobial defense was relatively unknown. Kaplan and colleagues now demonstrate that nociceptive fibers within the dermis play a crucial role in antifungal defenses through their influence on dermal dendritic cells and induction of IL-17A.
ISSN:	1074-7613 1097-4180
DOI:	10.1016/j.immuni.2015.08.025