Anti-neuroinflammatory effects of DPTP, a novel synthetic clovamide derivative in in vitro and in vivo model of neuroinflammation
Highlights • DPTP suppresses LPS-induced NO production in primary and BV-2 microglial cells. • DPTP reduced the LPS-induced expression of iNOS, COX-2 and cytokines in BV-2 cells. • DPTP suppressed the phopho-levels of ERK and JNK in LPS-activate BV-2 microglia. • DPTP abated the nuclear translocatio...
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| Veröffentlicht in: | Brain research bulletin 2015-03, Vol.112, p.25-34 |
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| creator | Lim, Hyung-Woo Park, Jeong-In More, Sandeep Vasant Park, Ju-Young Kim, Byung-Wook Jeon, Sae-Bom Yun, Yo-sep Park, Eun-Jung Yoon, Sung-Hwa Choi, Dong-Kug |
| description | Highlights • DPTP suppresses LPS-induced NO production in primary and BV-2 microglial cells. • DPTP reduced the LPS-induced expression of iNOS, COX-2 and cytokines in BV-2 cells. • DPTP suppressed the phopho-levels of ERK and JNK in LPS-activate BV-2 microglia. • DPTP abated the nuclear translocation of NF-κB by reducing the p-IκB-α levels. • DPTP reduced inflammatory markers induced by MPTP-induced neuroinflammation in mice. |
| doi_str_mv | 10.1016/j.brainresbull.2015.01.004 |
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Park, Jeong-In ; More, Sandeep Vasant ; Park, Ju-Young ; Kim, Byung-Wook ; Jeon, Sae-Bom ; Yun, Yo-sep ; Park, Eun-Jung ; Yoon, Sung-Hwa ; Choi, Dong-Kug</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-dcbc1b3b6ddfc5a2d8a1ab73f52e3bfcca3433f792ac3e003968e4c7d6a9af4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</topic><topic>Animals</topic><topic>Brain - drug effects</topic><topic>Brain - physiopathology</topic><topic>Cell Line</topic><topic>Cells, Cultured</topic><topic>Clovamide derivative</topic><topic>Disease Models, Animal</topic><topic>Extracellular Signal-Regulated MAP Kinases - metabolism</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - physiopathology</topic><topic>JNK Mitogen-Activated Protein Kinases - metabolism</topic><topic>Lipopolysaccharide</topic><topic>Lipopolysaccharides</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microglia</topic><topic>Microglia - drug effects</topic><topic>Microglia - physiology</topic><topic>MPTP</topic><topic>Neuroimmunomodulation - drug effects</topic><topic>Neuroimmunomodulation - physiology</topic><topic>Neuroinflammation</topic><topic>Neurology</topic><topic>Neuroprotective Agents - chemical synthesis</topic><topic>Neuroprotective Agents - chemistry</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>NF-kappa B - metabolism</topic><topic>Phosphorylation - drug effects</topic><topic>Rats, Sprague-Dawley</topic><topic>Tyrosine - analogs & derivatives</topic><topic>Tyrosine - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, Hyung-Woo</creatorcontrib><creatorcontrib>Park, Jeong-In</creatorcontrib><creatorcontrib>More, Sandeep Vasant</creatorcontrib><creatorcontrib>Park, Ju-Young</creatorcontrib><creatorcontrib>Kim, Byung-Wook</creatorcontrib><creatorcontrib>Jeon, Sae-Bom</creatorcontrib><creatorcontrib>Yun, Yo-sep</creatorcontrib><creatorcontrib>Park, Eun-Jung</creatorcontrib><creatorcontrib>Yoon, Sung-Hwa</creatorcontrib><creatorcontrib>Choi, Dong-Kug</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, Hyung-Woo</au><au>Park, Jeong-In</au><au>More, Sandeep Vasant</au><au>Park, Ju-Young</au><au>Kim, Byung-Wook</au><au>Jeon, Sae-Bom</au><au>Yun, Yo-sep</au><au>Park, Eun-Jung</au><au>Yoon, Sung-Hwa</au><au>Choi, Dong-Kug</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-neuroinflammatory effects of DPTP, a novel synthetic clovamide derivative in in vitro and in vivo model of neuroinflammation</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>112</volume><spage>25</spage><epage>34</epage><pages>25-34</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><abstract>Highlights • DPTP suppresses LPS-induced NO production in primary and BV-2 microglial cells. • DPTP reduced the LPS-induced expression of iNOS, COX-2 and cytokines in BV-2 cells. • DPTP suppressed the phopho-levels of ERK and JNK in LPS-activate BV-2 microglia. • DPTP abated the nuclear translocation of NF-κB by reducing the p-IκB-α levels. • DPTP reduced inflammatory markers induced by MPTP-induced neuroinflammation in mice.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25596423</pmid><doi>10.1016/j.brainresbull.2015.01.004</doi><tpages>10</tpages></addata></record> |
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| subjects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Brain - drug effects Brain - physiopathology Cell Line Cells, Cultured Clovamide derivative Disease Models, Animal Extracellular Signal-Regulated MAP Kinases - metabolism Inflammation - drug therapy Inflammation - physiopathology JNK Mitogen-Activated Protein Kinases - metabolism Lipopolysaccharide Lipopolysaccharides Male Mice Mice, Inbred C57BL Microglia Microglia - drug effects Microglia - physiology MPTP Neuroimmunomodulation - drug effects Neuroimmunomodulation - physiology Neuroinflammation Neurology Neuroprotective Agents - chemical synthesis Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology NF-kappa B - metabolism Phosphorylation - drug effects Rats, Sprague-Dawley Tyrosine - analogs & derivatives Tyrosine - chemistry |
| title | Anti-neuroinflammatory effects of DPTP, a novel synthetic clovamide derivative in in vitro and in vivo model of neuroinflammation |
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