Anti-neuroinflammatory effects of DPTP, a novel synthetic clovamide derivative in in vitro and in vivo model of neuroinflammation

Highlights • DPTP suppresses LPS-induced NO production in primary and BV-2 microglial cells. • DPTP reduced the LPS-induced expression of iNOS, COX-2 and cytokines in BV-2 cells. • DPTP suppressed the phopho-levels of ERK and JNK in LPS-activate BV-2 microglia. • DPTP abated the nuclear translocatio...

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Veröffentlicht in:	Brain research bulletin 2015-03, Vol.112, p.25-34
Hauptverfasser:	Lim, Hyung-Woo, Park, Jeong-In, More, Sandeep Vasant, Park, Ju-Young, Kim, Byung-Wook, Jeon, Sae-Bom, Yun, Yo-sep, Park, Eun-Jung, Yoon, Sung-Hwa, Choi, Dong-Kug
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Brain - drug effects Brain - physiopathology Cell Line Cells, Cultured Clovamide derivative Disease Models, Animal Extracellular Signal-Regulated MAP Kinases - metabolism Inflammation - drug therapy Inflammation - physiopathology JNK Mitogen-Activated Protein Kinases - metabolism Lipopolysaccharide Lipopolysaccharides Male Mice Mice, Inbred C57BL Microglia Microglia - drug effects Microglia - physiology MPTP Neuroimmunomodulation - drug effects Neuroimmunomodulation - physiology Neuroinflammation Neurology Neuroprotective Agents - chemical synthesis Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology NF-kappa B - metabolism Phosphorylation - drug effects Rats, Sprague-Dawley Tyrosine - analogs & derivatives Tyrosine - chemistry
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Zusammenfassung:	Highlights • DPTP suppresses LPS-induced NO production in primary and BV-2 microglial cells. • DPTP reduced the LPS-induced expression of iNOS, COX-2 and cytokines in BV-2 cells. • DPTP suppressed the phopho-levels of ERK and JNK in LPS-activate BV-2 microglia. • DPTP abated the nuclear translocation of NF-κB by reducing the p-IκB-α levels. • DPTP reduced inflammatory markers induced by MPTP-induced neuroinflammation in mice.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2015.01.004