A hybridisation-dependent membrane-insertable amphiphilic DNA

We synthesised a novel membrane-insertable amphiphilic DNA. The amphiphilic DNA had a nine-nucleotide hydrophobic region at one end consisting of octyl phosphotriester linkages. The amphiphilic DNA bound to the lipid membrane by inserting the hydrophobic region; this process was facilitated by the p...

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Veröffentlicht in:	Organic & biomolecular chemistry 2015-01, Vol.13 (40), p.10117-10121
Hauptverfasser:	Dohno, C, Matsuzaki, K, Yamaguchi, H, Shibata, T, Nakatani, K
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemical synthesis DNA - chemistry Esters - chemistry Hydrophobic and Hydrophilic Interactions Lipids - chemistry Liposomes - chemistry Molecular Structure Surface-Active Agents - chemical synthesis Surface-Active Agents - chemistry
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Beschreibung
Zusammenfassung:	We synthesised a novel membrane-insertable amphiphilic DNA. The amphiphilic DNA had a nine-nucleotide hydrophobic region at one end consisting of octyl phosphotriester linkages. The amphiphilic DNA bound to the lipid membrane by inserting the hydrophobic region; this process was facilitated by the presence of the complementary DNA strand.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/c5ob01761k