Toxic synergism between quinolinic acid and organic acids accumulating in glutaric acidemia type I and in disorders of propionate metabolism in rat brain synaptosomes: Relevance for metabolic acidemias

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Veröffentlicht in:	Neuroscience 2015-11, Vol.308, p.64-74
Hauptverfasser:	Colín-González, A.L, Paz-Loyola, A.L, Serratos, I, Seminotti, B, Ribeiro, C.A.J, Leipnitz, G, Souza, D.O, Wajner, M, Santamaría, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Metabolism, Inborn Errors - metabolism Animals Brain - drug effects Brain - metabolism Brain Diseases, Metabolic - metabolism cell damage Disease Models, Animal excitotoxicity Glutarates - metabolism Glutarates - toxicity Glutaryl-CoA Dehydrogenase - deficiency Glutaryl-CoA Dehydrogenase - metabolism Lipid Peroxidation - drug effects Male Methylmalonic Acid - metabolism Methylmalonic Acid - toxicity mitochondrial dysfunction Neurology Neuroprotective Agents - pharmacology organic acidemias oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Propionates - metabolism Propionates - toxicity Quinolinic Acid - metabolism Quinolinic Acid - toxicity Rats, Wistar Reactive Oxygen Species - metabolism Synaptosomes - drug effects Synaptosomes - metabolism toxic synergism
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