Evidence that the genetic polymorphism rs1412115 on chromosome 10 is associated with risk for oral squamous cell carcinoma

A genome-wide association study on schizophrenia in Jewish population discovered a novel single nucleotide polymorphism (SNP), rs1412115, on chromosome 10. It has been proved that neuropilin-1 (NRP-1) gene located on chromosome 10, tightly close to rs1412115, is associated with increased risk for oral squamous cell carcinoma (OSCC). In the present study, we hypothesized that SNP rs1412115:A>G is associated with increased risk for OSCC. We therefore genotyped this polymorphism in 295 patients with OSCC and 594 cancer-free controls in the Chinese Han population, using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectroscopy. The pooled odds ratio was 1.42 (95% confidence interval [CI]=1.01–1.99, p=0.042) for carriers with the A version of the allele (AA and AG) compared with GG, and 1.46 (95% CI=1.02–2.09, p=0.036) for AG compared with GG. Our data provide evidence that the rs1412115: A>G polymorphism increases the risk of OSCC in Chinese Han populations. Larger population-based studies are needed to confirm these results. •The relationship between rs1412115 and NRP-1 gene was first hypothesized.•The relationship between rs1412115 polymorphism and OSCC was first reported.•The SNP rs1412115 GG and AG genotypes were associated with susceptibility of OSCC.