PPARγ and IL-6 −174G>C gene variants in Croatian patients with ischemic stroke

PPARγ and IL-6 −174G>C gene variants in Croatian patients with ischemic stroke

Etiology of ischemic stroke (IS) is multifactorial and includes interaction of genetic and environmental factors. Different genes, their polymorphisms, host susceptibility, and inflammation processes play a role in IS development. The aim of this study was to evaluate the effect of PPAR-γ and IL-6 g...

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Veröffentlicht in:Gene 2015-04, Vol.560 (2), p.200-204
Hauptverfasser: Bazina, A., Sertić, J., Mišmaš, A., Lovrić, T., Poljaković, Z., Miličić, D.
Format: Artikel
Sprache:eng
Schlagworte:
Adults
Brain Ischemia - genetics
Case-Control Studies
Croatia
Female
Gene Frequency
Genes
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Interleukin-6 - genetics
Ischemic stroke
Male
Middle Aged
Polymorphism, Single Nucleotide
Polymorphisms
PPAR gamma - genetics
Risk Factors
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Zusammenfassung:Etiology of ischemic stroke (IS) is multifactorial and includes interaction of genetic and environmental factors. Different genes, their polymorphisms, host susceptibility, and inflammation processes play a role in IS development. The aim of this study was to evaluate the effect of PPAR-γ and IL-6 gene variants on IS onset. A total of 301 subjects (144 males, 157 females) participated in the study, 114 patients with IS and 187 healthy controls. Statistically significant predictors of IS were male gender (OR 7.13, 95% CI 2.92–17.39, p
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2015.02.003