Effect of tocopherol and acetylsalicylic acid on the biochemical indices of blood in dioxin-exposed rats

Effect of tocopherol and acetylsalicylic acid on the biochemical indices of blood in dioxin-exposed rats

Highlights • We determine whether tocopherol (TCDD) protects the central nervous system (CNS) by decreasing the pro-inflammatory reactions. • We examine whether acetylsalicylic acid (ASA) inhibits the production of inflammatory mediators. • We examine whether the combined administration of TCDD and...

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Veröffentlicht in:Environmental toxicology and pharmacology 2015-07, Vol.40 (1), p.1-11
Hauptverfasser: Rosiczuk, Joanna, Cakosiski, Ireneusz
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Ascorbic acid
Aspirin - pharmacology
Biochemical parameters
Blood
Dioxin
Emergency
Female
Inflammatory reaction
Male
Polychlorinated Dibenzodioxins - toxicity
Rats
Tocopherol
Tocopherols - pharmacology
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Zusammenfassung:Highlights • We determine whether tocopherol (TCDD) protects the central nervous system (CNS) by decreasing the pro-inflammatory reactions. • We examine whether acetylsalicylic acid (ASA) inhibits the production of inflammatory mediators. • We examine whether the combined administration of TCDD and ASA has a potential CNS protective effect. • TCDD improves protein metabolism by reducing protein catabolism. • Combined ASA and TCDD suppress catabolic processes accompanying inflammation.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.04.017