Intrinsic exercise capacity is related to differential monoaminergic activity in the rat forebrain

Highlights • The exercise variability is associated with differences in monoaminergic systems. • Rats with high capacity to exercise exhibit higher basal DA activity in CPu. • Moderate exercise (ME) until fatigue increases the DOPAC and DOPAC/DA ratio in CPu. • In rats with low exercise capacity, th...

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Veröffentlicht in:	Brain research bulletin 2015-03, Vol.112, p.7-13
Hauptverfasser:	Rabelo, P.C.R, Almeida, T.F, Guimarães, J.B, Barcellos, L.A.M, Cordeiro, L.M.S, Moraes, M.M, Coimbra, C.C, Szawka, R.E, Soares, D.D
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Accumbens Aerobic exercise Animals Biogenic Monoamines - metabolism Caudate Nucleus - metabolism Caudate–putamen Dopamine Dopamine - metabolism Fatigue Hydroxyindoleacetic Acid - metabolism Male Neurology Physical Fitness - physiology Putamen - metabolism Random Allocation Rats, Wistar Rest Serotonin Serotonin - metabolism
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Zusammenfassung:	Highlights • The exercise variability is associated with differences in monoaminergic systems. • Rats with high capacity to exercise exhibit higher basal DA activity in CPu. • Moderate exercise (ME) until fatigue increases the DOPAC and DOPAC/DA ratio in CPu. • In rats with low exercise capacity, the 5-HT variables do not change after ME.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2015.01.006