Alternative mRNA transcription, processing, and translation: insights from RNA sequencing

Highlights • RNA sequencing uncovers mechanisms regulating gene expression. • Use of alternative TSSs, PASs, and exons is the rule. • Alternative translation initiation at 5′-UTRs and downstream codons is widespread. • Transcription, RNA processing, and translation are often interdependent processes...

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Veröffentlicht in:	Trends in genetics 2015-03, Vol.31 (3), p.128-139
Hauptverfasser:	de Klerk, Eleonora, t Hoen, Peter A.C
Format:	Artikel
Sprache:	eng
Schlagworte:	alternative polyadenylation Alternative Splicing gene expression Gene Expression Profiling High-Throughput Nucleotide Sequencing - methods Humans Medical Education Polyadenylation Promoter Regions, Genetic - genetics Protein Biosynthesis RNA sequencing RNA, Messenger - genetics Sequence Analysis, RNA Transcription, Genetic Transcriptome translation
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights • RNA sequencing uncovers mechanisms regulating gene expression. • Use of alternative TSSs, PASs, and exons is the rule. • Alternative translation initiation at 5′-UTRs and downstream codons is widespread. • Transcription, RNA processing, and translation are often interdependent processes.
ISSN:	0168-9525
DOI:	10.1016/j.tig.2015.01.001