Stromal cell-derived CCL2 drives neuropathic pain states through myeloid cell infiltration in injured nerve

Highlights • Chronic neuropathic pain involves many persistent local proinflammatory processes. • The chemokine CCL2 plays a major role in the development of neuropathic pain. • Upregulation of CCL2 correlates with monocyte/macrophage infiltration and pain. • Neural CCL2 predominantly drives neuro-i...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-03, Vol.45, p.198-210
Hauptverfasser:	Van Steenwinckel, Juliette, Auvynet, Constance, Sapienza, Anaïs, Reaux-Le Goazigo, Annabelle, Combadière, Christophe, Melik Parsadaniantz, Stéphane
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Bone Marrow Transplantation CCL2 Chemokine Chemokine CCL2 - immunology Constriction, Pathologic FACS Hyperalgesia - genetics Hyperalgesia - immunology Irradiated bone marrow-chimeric mice Macrophages Macrophages - immunology Mice Monocytes - immunology Myeloid Cells - immunology Neuralgia - immunology Neuropathic pain Nociceptive behavior Peripheral Nerve Injuries - immunology Psychiatry Rats Sciatic Nerve - immunology Sciatic Nerve - injuries Up-Regulation
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Beschreibung
Zusammenfassung:	Highlights • Chronic neuropathic pain involves many persistent local proinflammatory processes. • The chemokine CCL2 plays a major role in the development of neuropathic pain. • Upregulation of CCL2 correlates with monocyte/macrophage infiltration and pain. • Neural CCL2 predominantly drives neuro-immune interactions during neuropathic pain.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2014.10.016