Neonatal glucocorticoid treatment: Long-term effects on the hypothalamus–pituitary–adrenal axis, immune system, and problem behavior in 14–17 year old adolescents

Highlights • Long-term effects of neonatal intervention with glucocorticoids in humans. • Neonatal dexamethasone treatment increases HPA-axis output during social stress. • Neonatal hydrocortisone treatment was unrelated to adverse outcome at age 14–17 years.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-03, Vol.45, p.128-138
Hauptverfasser:	ter Wolbeek, Maike, Kavelaars, Annemieke, de Vries, Willem B, Tersteeg-Kamperman, Marijke, Veen, Sylvia, Kornelisse, René F, van Weissenbruch, Mirjam, Baerts, Wim, Liem, Kian D, van Bel, Frank, Heijnen, Cobi J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescence Adolescent Adrenocorticotropic Hormone - metabolism Aggression - psychology Allergy and Immunology Anxiety - psychology Bronchopulmonary dysplasia Bronchopulmonary Dysplasia - prevention & control Case-Control Studies Cohort Studies Cortisol Cytokines Cytokines - immunology Depression - psychology Dexamethasone Dexamethasone - therapeutic use Female Gestational Age Glucocorticoid Glucocorticoids - therapeutic use HPA-axis Humans Hydrocortisone Hydrocortisone - metabolism Hydrocortisone - therapeutic use Hypothalamo-Hypophyseal System - metabolism Hypothalamo-Hypophyseal System - physiopathology Immune System - metabolism Immune System - physiopathology Infant, Newborn Infant, Premature Interferon-gamma - immunology Interleukin-10 - immunology Interleukin-4 - immunology Interleukin-6 - immunology Longitudinal Studies Male Neonatal Pituitary-Adrenal System - metabolism Pituitary-Adrenal System - physiopathology Problem behavior Psychiatry Saliva - chemistry Sex Factors Stress, Psychological - metabolism Stress, Psychological - physiopathology Tumor Necrosis Factor-alpha - immunology
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Beschreibung
Zusammenfassung:	Highlights • Long-term effects of neonatal intervention with glucocorticoids in humans. • Neonatal dexamethasone treatment increases HPA-axis output during social stress. • Neonatal hydrocortisone treatment was unrelated to adverse outcome at age 14–17 years.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2014.10.017