The role of inflammatory cytokines as key modulators of neurogenesis

The role of inflammatory cytokines as key modulators of neurogenesis

Highlights • An overview of the effect of inflammatory cytokines on neurogenesis. • In vitro studies were selected, including both human and animal cellular models. • Cytokines have both positive and negative roles on proliferation and neurogenesis. • Same cytokines differently modulate specific sig...

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Veröffentlicht in:Trends in neurosciences (Regular ed.) 2015-03, Vol.38 (3), p.145-157
Hauptverfasser: Borsini, Alessandra, Zunszain, Patricia A, Thuret, Sandrine, Pariante, Carmine M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain - physiology
Brain research
cell differentiation
Cell Proliferation - physiology
Cytokines
Cytokines - metabolism
Humans
immune activation
Immune system
inflammation
interleukins
Mental disorders
Neurogenesis
Neurogenesis - physiology
Neurology
Neurosciences
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Beschreibung
Zusammenfassung:Highlights • An overview of the effect of inflammatory cytokines on neurogenesis. • In vitro studies were selected, including both human and animal cellular models. • Cytokines have both positive and negative roles on proliferation and neurogenesis. • Same cytokines differently modulate specific signalling pathways in human and animal models. • Diverse brain regions have specific proliferating and differentiating properties.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2014.12.006