Type 2 diabetes reduces the proliferation and survival of oligodendrocyte progenitor cells in ishchemic white matter lesions
Highlights • Ischemic white matter lesion was exacerbated in db / db mice. • Proliferation of oligodendrocyte progenitors (OPCs) were attenuated in ischemic white matter of diabetes. • Less survival and maturation of OPCs were critical for ischemic white matter lesion in diabetes. • Mobilization of...
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| Veröffentlicht in: | Neuroscience 2015-03, Vol.289, p.214-223 |
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| container_title | Neuroscience |
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| creator | Yatomi, Y Tanaka, R Shimada, Y Yamashiro, K Liu, M Mitome-Mishima, Y Miyamoto, N Ueno, Y Urabe, T Hattori, N |
| description | Highlights • Ischemic white matter lesion was exacerbated in db / db mice. • Proliferation of oligodendrocyte progenitors (OPCs) were attenuated in ischemic white matter of diabetes. • Less survival and maturation of OPCs were critical for ischemic white matter lesion in diabetes. • Mobilization of OPCs may play an important role in the white matter lesion in diabetes. |
| doi_str_mv | 10.1016/j.neuroscience.2014.12.054 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-3893d31c1aedf85a23e7ee28db1956d2d05b72134facf4860d7617e1dfa7081b3</citedby><cites>FETCH-LOGICAL-c534t-3893d31c1aedf85a23e7ee28db1956d2d05b72134facf4860d7617e1dfa7081b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306452215000226$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25592431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yatomi, Y</creatorcontrib><creatorcontrib>Tanaka, R</creatorcontrib><creatorcontrib>Shimada, Y</creatorcontrib><creatorcontrib>Yamashiro, K</creatorcontrib><creatorcontrib>Liu, M</creatorcontrib><creatorcontrib>Mitome-Mishima, Y</creatorcontrib><creatorcontrib>Miyamoto, N</creatorcontrib><creatorcontrib>Ueno, Y</creatorcontrib><creatorcontrib>Urabe, T</creatorcontrib><creatorcontrib>Hattori, N</creatorcontrib><title>Type 2 diabetes reduces the proliferation and survival of oligodendrocyte progenitor cells in ishchemic white matter lesions</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Highlights • Ischemic white matter lesion was exacerbated in db / db mice. • Proliferation of oligodendrocyte progenitors (OPCs) were attenuated in ischemic white matter of diabetes. • Less survival and maturation of OPCs were critical for ischemic white matter lesion in diabetes. • Mobilization of OPCs may play an important role in the white matter lesion in diabetes.</description><subject>Animals</subject><subject>Apoptosis - physiology</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brain Ischemia - pathology</subject><subject>Brain Ischemia - physiopathology</subject><subject>Carotid Stenosis</subject><subject>Cell Proliferation - physiology</subject><subject>Cell Survival - physiology</subject><subject>chronic ischemia</subject><subject>dementia</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Glutathione S-Transferase pi - metabolism</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Male</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Mutant Strains</subject><subject>Neural Stem Cells - pathology</subject><subject>Neural Stem Cells - physiology</subject><subject>Neurology</subject><subject>oligodendrocyte progenitors</subject><subject>Oligodendroglia - pathology</subject><subject>Oligodendroglia - physiology</subject><subject>Receptor, Platelet-Derived Growth Factor alpha - metabolism</subject><subject>White Matter - pathology</subject><subject>White Matter - physiopathology</subject><subject>white matter lesion</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk-P0zAQxS0EYruFr4AsTlwSPHYcpxyQ0AIL0kocWM6WY0-2LvlTbKerSnx4HFoQ4gK-zMG_eTOa9wh5DqwEBvXLXTniHKZoPY4WS86gKoGXTFYPyAoaJQolq-ohWTHB6qKSnF-Qyxh3LD9Zicfkgku54ZWAFfl-e9wj5dR502LCSAO62eaatkj3Yep9h8EkP43UjI7GORz8wfR06mj-u5scji5M9ph-0nc4-jQFarHvI_Uj9XFrtzh4S--3PjODSQkD7TFmxfiEPOpMH_Hpua7Jl_fvbq8-FDefrj9evbkprBRVKkSzEU6ABYOua6ThAhUib1wLG1k77phsFQdRdcZ2VVMzp2pQCK4zijXQijV5cdLNK36bMSY9-LjsaEac5qhBcVWregPq32itBFNyAyKjr06ozV7EgJ3eBz-YcNTA9GKU3uk_jdKLURq4XkxYk2fnOXM7oPvd-suZDLw9AZgPc_AY9FnG-YA2aTf5_5vz-i8Z2_vRW9N_xSPG3TSHMZ9eg465QX9eIrMkBmQOC-e1-AHC2sKY</recordid><startdate>20150319</startdate><enddate>20150319</enddate><creator>Yatomi, Y</creator><creator>Tanaka, R</creator><creator>Shimada, Y</creator><creator>Yamashiro, K</creator><creator>Liu, M</creator><creator>Mitome-Mishima, Y</creator><creator>Miyamoto, N</creator><creator>Ueno, Y</creator><creator>Urabe, T</creator><creator>Hattori, N</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20150319</creationdate><title>Type 2 diabetes reduces the proliferation and survival of oligodendrocyte progenitor cells in ishchemic white matter lesions</title><author>Yatomi, Y ; Tanaka, R ; Shimada, Y ; Yamashiro, K ; Liu, M ; Mitome-Mishima, Y ; Miyamoto, N ; Ueno, Y ; Urabe, T ; Hattori, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-3893d31c1aedf85a23e7ee28db1956d2d05b72134facf4860d7617e1dfa7081b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Apoptosis - physiology</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Brain Ischemia - pathology</topic><topic>Brain Ischemia - physiopathology</topic><topic>Carotid Stenosis</topic><topic>Cell Proliferation - physiology</topic><topic>Cell Survival - physiology</topic><topic>chronic ischemia</topic><topic>dementia</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Type 2 - pathology</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Glutathione S-Transferase pi - metabolism</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Male</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Mutant Strains</topic><topic>Neural Stem Cells - pathology</topic><topic>Neural Stem Cells - physiology</topic><topic>Neurology</topic><topic>oligodendrocyte progenitors</topic><topic>Oligodendroglia - pathology</topic><topic>Oligodendroglia - physiology</topic><topic>Receptor, Platelet-Derived Growth Factor alpha - metabolism</topic><topic>White Matter - pathology</topic><topic>White Matter - physiopathology</topic><topic>white matter lesion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yatomi, Y</creatorcontrib><creatorcontrib>Tanaka, R</creatorcontrib><creatorcontrib>Shimada, Y</creatorcontrib><creatorcontrib>Yamashiro, K</creatorcontrib><creatorcontrib>Liu, M</creatorcontrib><creatorcontrib>Mitome-Mishima, Y</creatorcontrib><creatorcontrib>Miyamoto, N</creatorcontrib><creatorcontrib>Ueno, Y</creatorcontrib><creatorcontrib>Urabe, T</creatorcontrib><creatorcontrib>Hattori, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yatomi, Y</au><au>Tanaka, R</au><au>Shimada, Y</au><au>Yamashiro, K</au><au>Liu, M</au><au>Mitome-Mishima, Y</au><au>Miyamoto, N</au><au>Ueno, Y</au><au>Urabe, T</au><au>Hattori, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type 2 diabetes reduces the proliferation and survival of oligodendrocyte progenitor cells in ishchemic white matter lesions</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2015-03-19</date><risdate>2015</risdate><volume>289</volume><spage>214</spage><epage>223</epage><pages>214-223</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>Highlights • Ischemic white matter lesion was exacerbated in db / db mice. • Proliferation of oligodendrocyte progenitors (OPCs) were attenuated in ischemic white matter of diabetes. • Less survival and maturation of OPCs were critical for ischemic white matter lesion in diabetes. • Mobilization of OPCs may play an important role in the white matter lesion in diabetes.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>25592431</pmid><doi>10.1016/j.neuroscience.2014.12.054</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Apoptosis - physiology Brain - pathology Brain - physiopathology Brain Ischemia - pathology Brain Ischemia - physiopathology Carotid Stenosis Cell Proliferation - physiology Cell Survival - physiology chronic ischemia dementia diabetes Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Disease Models, Animal Glutathione S-Transferase pi - metabolism Ki-67 Antigen - metabolism Male Mice, Inbred C57BL Mice, Mutant Strains Neural Stem Cells - pathology Neural Stem Cells - physiology Neurology oligodendrocyte progenitors Oligodendroglia - pathology Oligodendroglia - physiology Receptor, Platelet-Derived Growth Factor alpha - metabolism White Matter - pathology White Matter - physiopathology white matter lesion |
| title | Type 2 diabetes reduces the proliferation and survival of oligodendrocyte progenitor cells in ishchemic white matter lesions |
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