Type 2 diabetes reduces the proliferation and survival of oligodendrocyte progenitor cells in ishchemic white matter lesions

Highlights • Ischemic white matter lesion was exacerbated in db / db mice. • Proliferation of oligodendrocyte progenitors (OPCs) were attenuated in ischemic white matter of diabetes. • Less survival and maturation of OPCs were critical for ischemic white matter lesion in diabetes. • Mobilization of...

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Veröffentlicht in:	Neuroscience 2015-03, Vol.289, p.214-223
Hauptverfasser:	Yatomi, Y, Tanaka, R, Shimada, Y, Yamashiro, K, Liu, M, Mitome-Mishima, Y, Miyamoto, N, Ueno, Y, Urabe, T, Hattori, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Brain - pathology Brain - physiopathology Brain Ischemia - pathology Brain Ischemia - physiopathology Carotid Stenosis Cell Proliferation - physiology Cell Survival - physiology chronic ischemia dementia diabetes Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Disease Models, Animal Glutathione S-Transferase pi - metabolism Ki-67 Antigen - metabolism Male Mice, Inbred C57BL Mice, Mutant Strains Neural Stem Cells - pathology Neural Stem Cells - physiology Neurology oligodendrocyte progenitors Oligodendroglia - pathology Oligodendroglia - physiology Receptor, Platelet-Derived Growth Factor alpha - metabolism White Matter - pathology White Matter - physiopathology white matter lesion
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Zusammenfassung:	Highlights • Ischemic white matter lesion was exacerbated in db / db mice. • Proliferation of oligodendrocyte progenitors (OPCs) were attenuated in ischemic white matter of diabetes. • Less survival and maturation of OPCs were critical for ischemic white matter lesion in diabetes. • Mobilization of OPCs may play an important role in the white matter lesion in diabetes.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.12.054