Interethnic variability of CYP4F2 (V433M) in admixed population of Roma and Hungarians

Interethnic variability of CYP4F2 (V433M) in admixed population of Roma and Hungarians

Highlights • First study on functional CYP4F2 (V433M) SNP in Roma and Hungarian populations. • Marginal interethnic differences of CYP4F2*3 missense variant could be revealed. • This allele is more common in Roma (0.32) than in Hungarian's (0.23). • Roma carrier frequency (53.5%) suggest the ne...

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Veröffentlicht in:Environmental toxicology and pharmacology 2015-07, Vol.40 (1), p.280-283
Hauptverfasser: Sipeky, Csilla, Weber, Agnes, Melegh, Bela I, Matyas, Petra, Janicsek, Ingrid, Szalai, Renata, Szabo, Istvan, Varnai, Reka, Tarlos, Greta, Ganczer, Alma, Melegh, Bela
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Aged, 80 and over
CYP4F23 (rs2108622, V433M)
Cytochrome P-450 Enzyme System - genetics
Cytochrome P450 Family 4
Emergency
Ethnic Groups - genetics
Female
Humans
Hungarian
Hungary
Male
Middle Aged
Population pharmacogenetics
Roma
Young Adult
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Beschreibung
Zusammenfassung:Highlights • First study on functional CYP4F2 (V433M) SNP in Roma and Hungarian populations. • Marginal interethnic differences of CYP4F2*3 missense variant could be revealed. • This allele is more common in Roma (0.32) than in Hungarian's (0.23). • Roma carrier frequency (53.5%) suggest the need for higher daily mean warfarin dose. • Roma have elevated probability for under-anticoagulation in long-term warfarin use.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.05.008