Sibutramine, a serotonin–norepinephrine reuptake inhibitor, causes fibrosis in rats

Sibutramine, a serotonin–norepinephrine reuptake inhibitor, causes fibrosis in rats

Highlights • Sibutramine induces lung fibrosis. • Increased collagen synthesis was observed. • Mast cell accumulation was found. • Aggregates of BALT was seen.

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Veröffentlicht in:Environmental toxicology and pharmacology 2015-07, Vol.40 (1), p.71-76
Hauptverfasser: Oberholzer, Hester Magdalena, van der Schoor, Ciska, Bester, Megan Jean
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Appetite Depressants - toxicity
Collagen
Cyclobutanes - toxicity
Emergency
Female
Fibrosis
iBALT
Liver Cirrhosis - chemically induced
Mast cells
Neurotransmitter Uptake Inhibitors - toxicity
Rats
Rats, Sprague-Dawley
Sibutramine
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Zusammenfassung:Highlights • Sibutramine induces lung fibrosis. • Increased collagen synthesis was observed. • Mast cell accumulation was found. • Aggregates of BALT was seen.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.05.011