Different mutation profiles and clinical characteristics among Hispanic patients with non-small cell lung cancer could explain the “Hispanic paradox”

Different mutation profiles and clinical characteristics among Hispanic patients with non-small cell lung cancer could explain the “Hispanic paradox”

Highlights • It has been reported an advantage in overall survival in Hispanic populations. • We analyzed an Hispanic cohort of NSCLC patients cohort to explain this paradox. • We found a high prevalence of EGFR mutations and WSE among our population, particularly in women. • NSCLC risk factors diff...

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Veröffentlicht in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2015-11, Vol.90 (2), p.161-166
Hauptverfasser: Arrieta, Oscar, Ramírez-Tirado, Laura-Alejandra, Báez-Saldaña, Renata, Peña-Curiel, Omar, Soca-Chafre, Giovanny, Macedo-Perez, Eleazar-Omar
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma
Carcinoma, Large Cell - genetics
Carcinoma, Large Cell - pathology
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
ErbB Receptors - genetics
erbB-1
Female
Gene expression
Hematology, Oncology and Palliative Medicine
Hispanic Americans
Hispanic or Latino
Human
Humans
KRAS Protein
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Mexico
Middle Aged
Mutation
Mutation - genetics
Non-Small-Cell Lung
Prognosis
Pulmonary/Respiratory
ras Proteins - genetics
Smoke - adverse effects
Smoking - adverse effects
Young Adult
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Zusammenfassung:Highlights • It has been reported an advantage in overall survival in Hispanic populations. • We analyzed an Hispanic cohort of NSCLC patients cohort to explain this paradox. • We found a high prevalence of EGFR mutations and WSE among our population, particularly in women. • NSCLC risk factors differences between the two populations may explain the difference in survival.
ISSN:0169-5002
1872-8332
1872-8332
DOI:10.1016/j.lungcan.2015.08.010