The changing landscape of ischaemic brain injury mechanisms

Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanisms of ischaemic brain injury, and present a perspective that broadening of...

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Veröffentlicht in:	Nature (London) 1999-06, Vol.399 (Supplementary), p.A7-A14
Hauptverfasser:	Lee, Jin-Moo, Zipfel, Gregory J, Choi, Dennis W
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Brain damage Brain Ischemia - etiology Brain Ischemia - pathology Brain Ischemia - therapy Calcium - metabolism Forecasting Head injuries Humanities and Social Sciences Humans multidisciplinary Neurological disorders Potassium - metabolism Receptors, N-Methyl-D-Aspartate - metabolism review-article Science Science (multidisciplinary) Thrombolytic Therapy Zinc - toxicity
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Zusammenfassung:	Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanisms of ischaemic brain injury, and present a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload will be desirable for developing the most effective neuroprotective therapies.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/399a007