Occupational health survey on workers exposed to 2-bromopropane at low concentrations

Background Recent case studies in Korea and animal studies revealed the reproductive and hematopoietic toxicity of 2‐bromopropane introduced into workplaces as an alternative to ozone‐layer depleting chlorofluorocarbons. We aimed to clarify the dose‐effect relationship of 2‐bromopropane in workers. Method The exposure concentration of 2‐bromopropane and hematological indices, hormonal levels, menstruation status, and sperm indices were examined in 25 workers (11 males, 14 females) at a 2‐bromopropane factory. Regression analyses of the examined indices against time‐weighted average (TWA) of exposure concentration were conducted. Results Amenorrhea or polymenorrhea was observed only in older females. Hematological indices had a significant relation with TWA of exposure concentration in females with normal menstruation. However, no other indices showed any significant relation with TWA of 2‐bromopropane. Conclusions No severe cases of reproductive or hematopoietic disorders were found at less than 10 ppm (TWA), but a possible adverse effect of 2‐bromopropane on hematopoiesis could not be disproved. Am. J. Ind. Med 35:523–531, 1999. © 1999 Wiley‐Liss, Inc.