Vitamin K status is not associated with cognitive decline in middle aged adults
OBJECTIVES: The aim of this study was to examine the association between dephospho-uncarboxylated matrix Gla protein (dp-ucMGP), an indicator of vitamin K status, and cognitive decline, and the modifying role of 25(OH)D. DESIGN: Longitudinal study with six years follow-up. SETTING: Community based....
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Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2015-11, Vol.19 (9), p.908-912 |
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Sprache: | eng |
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Zusammenfassung: | OBJECTIVES: The aim of this study was to examine the association between dephospho-uncarboxylated matrix Gla protein (dp-ucMGP), an indicator of vitamin K status, and cognitive decline, and the modifying role of 25(OH)D. DESIGN: Longitudinal study with six years follow-up. SETTING: Community based. PARTICIPANTS: 599 participants of the Longitudinal Aging Study Amsterdam (aged 55-65 years). MEASUREMENTS: Information processing speed and a composite Z-score by combining three domains of cognition reflecting general cognitive functioning. RESULTS: Generalized estimating equations (GEE) showed no significant associations between dp-ucMGP and decline in general cognitive functioning. Vitamin D modified the association between dp-ucMGP and speed of information processing (p 50 nmol/l, the highest tertile of dp-ucMGP (>406 pmol/l), which corresponds to lower vitamin K levels, was associated with 1.5 higher score on information processing speed (p=0.023) as compared to the lowest tertile of dp-ucMGP. CONCLUSION: In contrast to our hypothesis, a suboptimal vitamin K was not associated with cognitive decline in middle-aged adults. |
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ISSN: | 1279-7707 1760-4788 |
DOI: | 10.1007/s12603-015-0579-8 |