DTI-based tractography of the arcuate fasciculus in patients with polymicrogyria and language disorders

Highlights • Patients with PMG commonly present with language disorders. • DTI-tractography allows parcellation and quantitative analysis of brain WM. • The AF is a major association tract involved in human language. • DTI-tractography demonstrates several qualitative and quantitative abnormalities...

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Veröffentlicht in:	European journal of radiology 2015-11, Vol.84 (11), p.2280-2286
Hauptverfasser:	Andrade, Celi S, Figueiredo, Kenya G, Valeriano, Cassia, Mendoza, Melanie, Valente, Kette D.R, Otaduy, Maria C.G, Leite, Claudia C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Brain - pathology Brain Mapping - methods Diffusion Tensor Imaging - methods Diffusion tensor imaging – fiber tractography Female Humans Language disorders Language Disorders - complications Language Disorders - pathology Magnetic resonance imaging Male Malformations of cortical development Polymicrogyria Polymicrogyria - complications Polymicrogyria - pathology Prospective Studies Radiology Young Adult
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Zusammenfassung:	Highlights • Patients with PMG commonly present with language disorders. • DTI-tractography allows parcellation and quantitative analysis of brain WM. • The AF is a major association tract involved in human language. • DTI-tractography demonstrates several qualitative and quantitative abnormalities of the AF in PMG. • Disrupted AF may constitute an anatomical substrate for language disorders in PMG.
ISSN:	0720-048X 1872-7727
DOI:	10.1016/j.ejrad.2015.07.014