The role of ABC transporters in ovarian cancer progression and chemoresistance

Highlights • Increased expression of ABC transporters is one cause of chemoresistance. • This review summarises the roles of all 48 ABC transporters in ovarian cancer. • Current list of chemotherapy drugs transported by ABC transporters. • Summary of ABC transporter inhibitors and studies/trials ass...

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Veröffentlicht in:	Critical reviews in oncology/hematology 2015-11, Vol.96 (2), p.220-256
Hauptverfasser:	Ween, M.P, Armstrong, M.A, Oehler, M.K, Ricciardelli, C
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter ATP-Binding Cassette Transporters - metabolism Chemoresistance Clinical trials Disease Progression Drug Resistance, Multiple - physiology Drug Resistance, Neoplasm - physiology Female Hematology, Oncology and Palliative Medicine Humans Multi-drug resistance Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Prognosis
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Beschreibung
Zusammenfassung:	Highlights • Increased expression of ABC transporters is one cause of chemoresistance. • This review summarises the roles of all 48 ABC transporters in ovarian cancer. • Current list of chemotherapy drugs transported by ABC transporters. • Summary of ABC transporter inhibitors and studies/trials assessing therapeutic benefit. • A better understanding of their function will lead to more effective therapies.
ISSN:	1040-8428 1879-0461
DOI:	10.1016/j.critrevonc.2015.05.012