Strategies targeting the IL-4/IL-13 axes in disease

IL-4 and IL-13 are pleiotropic Th2 cytokines produced by a wide variety of different cell types and responsible for a broad range of biology and functions. Physiologically, Th2 cytokines are known to mediate host defense against parasites but they can also trigger disease if their activities are dys...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2015-09, Vol.75 (1), p.89-116
Hauptverfasser:	May, Richard D., Fung, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - chemistry Antibody Asthma - metabolism Autoimmune Diseases - metabolism Autoimmunity Biologic Dermatitis, Atopic - metabolism Fibrosis - metabolism Gene Expression Regulation Humans Inflammation - metabolism Inflammatory Bowel Diseases - metabolism Interleukin-13 Interleukin-13 - metabolism Interleukin-4 Interleukin-4 - metabolism Mice Mice, Transgenic Mucous Membrane - metabolism Neoplasms - metabolism Polymorphism, Genetic Pulmonary Disease, Chronic Obstructive - metabolism Rhinitis, Allergic - metabolism Skin - immunology Th2 Cells - cytology Therapeutic
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Beschreibung
Zusammenfassung:	IL-4 and IL-13 are pleiotropic Th2 cytokines produced by a wide variety of different cell types and responsible for a broad range of biology and functions. Physiologically, Th2 cytokines are known to mediate host defense against parasites but they can also trigger disease if their activities are dysregulated. In this review we discuss the rationale for targeting the IL-4/IL-13 axes in asthma, atopic dermatitis, allergic rhinitis, COPD, cancer, inflammatory bowel disease, autoimmune disease and fibrotic disease as well as evaluating the associated clinical data derived from blocking IL-4, IL-13 or IL-4 and IL-13 together.
ISSN:	1043-4666 1096-0023
DOI:	10.1016/j.cyto.2015.05.018