Potency and penetration of telavancin in staphylococcal biofilms

Potency and penetration of telavancin in staphylococcal biofilms

Highlights • Staphylococcal biofilms were grown in drip-flow and capillary flow-cell reactors. • Telavancin-treated biofilms had significantly reduced mean log densities. • Antibiotics were visualised penetrating a Staphylococcus aureus biofilm.

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Veröffentlicht in:International journal of antimicrobial agents 2015-10, Vol.46 (4), p.451-455
Hauptverfasser: Kirker, Kelly R, Fisher, Steve T, James, Garth A
Format: Artikel
Sprache:eng
Schlagworte:
Aminoglycosides - pharmacology
Anti-Bacterial Agents - pharmacology
Biofilm
Biofilms - drug effects
Humans
Infectious Disease
Staphylococcal
Staphylococcus aureus - drug effects
Staphylococcus aureus - physiology
Staphylococcus epidermidis - drug effects
Staphylococcus epidermidis - physiology
Telavancin
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Zusammenfassung:Highlights • Staphylococcal biofilms were grown in drip-flow and capillary flow-cell reactors. • Telavancin-treated biofilms had significantly reduced mean log densities. • Antibiotics were visualised penetrating a Staphylococcus aureus biofilm.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2015.05.022