Pre-stimulus alpha and post-stimulus N2 foreshadow imminent errors in a single task

Performance errors have been attributed to distinct neural mechanisms in different tasks. Two temporally and physiologically dissociable neural patterns prior to errors, i.e., pre-stimulus alpha (8–13Hz) power indicative of sustained attention and post-stimulus N2 amplitude indicative of cognitive control, have been widely (but independently) reported in many studies. However, it is still largely unknown whether these two neural mechanisms for error commission exist in a single task at the same time and, if so, whether they can be probed simultaneously and how they lead to response accuracy (collectively or separately). To this end, we measured high-density electroencephalography (EEG) signals in a color–word matching Stroop task. We quantified both patterns on EEG data from individual stimulus condition (congruent or incongruent), as well as on pooled data from both conditions. Enhanced pre-stimulus alpha power for errors was identified over the parieto-occipital area in the congruent condition and the pooled data. Reduced post-stimulus N2 amplitude was only revealed in the incongruent condition. More importantly, for the first time, a balanced interaction between these two EEG patterns was revealed in correct trials, but not in error trials. These findings suggest that errors in one task could occur due to distinct neural mechanisms, e.g., poor sustained attention, poor cognitive control, or missed balance between these two. The present results further suggest that the detection of neural patterns related to different neural mechanisms could be complicated by other modulation factors, such as stimulus condition. Therefore, more than one neural marker should be simultaneously monitored to effectively predict imminent errors. •Detection of two different neural correlates linked to error in one task.•Elevated pre-stimulus alpha power indicating reduced sustained attention predicts error.•Reduced N2 amplitude suggesting deficits in cognitive control predicts error.•Balanced pre-stimulus alpha power and N2 amplitude in accurate responses.•Sustained attention and cognitive control jointly determine behavior outcome.