Farnesol prevents Fe-NTA-mediated renal oxidative stress and early tumour promotion markers in rats

Excess iron deposition in tissues leads to organ dysfunction and impairment. In this study, the protective effects of farnesol (FL), an isoprenoid, against Fe-NTA (9 mg iron/kg body weight i.p.)-induced oxidative damage and early tumour promotion markers are evaluated. The pretreatment of iron-intox...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human & experimental toxicology 2006-05, Vol.25 (5), p.235-242
Hauptverfasser:	Jahangir, Tamanna, Khan, Tajdar Husain, Prasad, Lakshmi, Sultana, Sarwat
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Antioxidants - pharmacology Biological and medical sciences Biomarkers, Tumor Blood Urea Nitrogen Cancer Carcinogenesis, carcinogens and anticarcinogens Carcinogens - toxicity Cell cycle Chemical agents DNA - metabolism Enzymes Farnesol - pharmacology Ferric Compounds - toxicity Glutathione - metabolism Glutathione Transferase - metabolism Hydrogen Peroxide - metabolism Iron Kidney - drug effects Kidney - metabolism Lipid Peroxidation - drug effects Male Medical sciences Microsomes - drug effects Microsomes - metabolism Nitrilotriacetic Acid - analogs & derivatives Nitrilotriacetic Acid - toxicity Ornithine Decarboxylase - metabolism Oxidative stress Oxidative Stress - drug effects Oxidoreductases - metabolism Rats Rats, Wistar Toxicity Toxicology Tumors
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Excess iron deposition in tissues leads to organ dysfunction and impairment. In this study, the protective effects of farnesol (FL), an isoprenoid, against Fe-NTA (9 mg iron/kg body weight i.p.)-induced oxidative damage and early tumour promotion markers are evaluated. The pretreatment of iron-intoxicated rats with 1% and 2%/kg body weight oral dose of FL for 7 consecutive days significantly reversed the iron-induced increase in H2O2 content (P
ISSN:	0960-3271 1477-0903
DOI:	10.1191/0960327106ht616oa