Thermodynamic Analysis of Allosteric and Chelate Cooperativity in Di- and Trivalent Ammonium/Crown-Ether Pseudorotaxanes

Thermodynamic Analysis of Allosteric and Chelate Cooperativity in Di- and Trivalent Ammonium/Crown-Ether Pseudorotaxanes

A detailed thermodynamic analysis of the axle-wheel binding in di- and trivalent secondary ammonium/[24]­crown-8 pseudorotaxanes is presented. Isothermal titration calorimetry (ITC) data and double mutant cycle analyses reveal an interesting interplay of positive as well as negative allosteric and p...

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Veröffentlicht in:Organic letters 2015-10, Vol.17 (20), p.5076-5079
Hauptverfasser: Nowosinski, Karol, von Krbek, Larissa K. S, Traulsen, Nora L, Schalley, Christoph A
Format: Artikel
Sprache:eng
Schlagworte:
Crown Ethers - chemistry
Humans
Magnetic Resonance Spectroscopy
Models, Chemical
Molecular Structure
Quaternary Ammonium Compounds - chemistry
Rotaxanes - chemistry
Thermodynamics
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Zusammenfassung:A detailed thermodynamic analysis of the axle-wheel binding in di- and trivalent secondary ammonium/[24]­crown-8 pseudorotaxanes is presented. Isothermal titration calorimetry (ITC) data and double mutant cycle analyses reveal an interesting interplay of positive as well as negative allosteric and positive chelate cooperativity thus providing profound insight into the effects governing multivalent binding in these pseudorotaxanes.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b02592