Acute pulmonary toxicity of acrolein in rats-underlying mechanism

Acute exposure of rats to acrolein (1 or 2 ppm) resulted in reduced levels of glutathione, ascorbic acid and α-tocopherol. The activities of catalase and glutathione peroxidase were reduced whereas an increase in the activities of superoxide dismutase was observed. This led to enhanced lipid peroxid...

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Veröffentlicht in:	Toxicology letters 1999-02, Vol.104 (3), p.189-194
Hauptverfasser:	Arumugam, N., Sivakumar, V., Thanislass, J., Sadasivan Pillai, K., Niranjali Devaraj, S., Devaraj, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein Acrolein - toxicity Acute Disease Animals Antioxidant enzymes Ascorbic Acid - metabolism Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Glutathione - metabolism Lipid peroxidation Lipid Peroxidation - drug effects Lung Lung - drug effects Lung - metabolism Lung Diseases - chemically induced Lung Diseases - metabolism Male Medical sciences Oxidation-Reduction Rats Rats, Wistar Sulfhydryl Compounds - metabolism Toxicology Various organic compounds Vitamin E - metabolism
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Zusammenfassung:	Acute exposure of rats to acrolein (1 or 2 ppm) resulted in reduced levels of glutathione, ascorbic acid and α-tocopherol. The activities of catalase and glutathione peroxidase were reduced whereas an increase in the activities of superoxide dismutase was observed. This led to enhanced lipid peroxidation, which produced extensive lung damage as indicated by the elevated levels of the biochemical markers—angiotensin converting enzyme, lactate dehydrogenase, protein and lactate in the bronchoalveolar lavage.
ISSN:	0378-4274 1879-3169
DOI:	10.1016/S0378-4274(98)00370-1