Mechanical consequences of allergic induced remodeling on mice airway resistance and compressibility

Highlights • We studied the mechanical consequences of airway remodeling in mice. • We examined the relationship between maximal tidal expiratory flow and airflow resistance following methacholine-induced bronchoconstriction in mice subjected to acute and chronic antigen challenge protocols. • The results we obtained show that the technique employed has promise for providing novel insight on the role of airway remodeling in airway hyperresponsiveness.