Preclinical Comparison of the Amyloid-β Radioligands [11C]Pittsburgh compound B and [18F]florbetaben in Aged APPPS1-21 and BRI1-42 Mouse Models of Cerebral Amyloidosis

Purpose The aim of this study was to compare [ 11 C]Pittsburgh compound B ([ 11 C]PiB) and [ 18 F]florbetaben ([ 18 F]FBB) for preclinical investigations of amyloid-β pathology. Procedures We investigated two aged animal models of cerebral amyloidosis with contrasting levels of amyloid-β relating to...

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Veröffentlicht in:	Molecular imaging and biology 2015-10, Vol.17 (5), p.688-696
Hauptverfasser:	Waldron, Ann-Marie, Verhaeghe, Jeroen, wyffels, Leonie, Schmidt, Mark, Langlois, Xavier, Van Der Linden, Annemie, Stroobants, Sigrid, Staelens, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Aniline Compounds - chemistry Aniline Compounds - metabolism Animals Disease Models, Animal Imaging Immunohistochemistry Medicine Medicine & Public Health Mice Positron-Emission Tomography Radiology Radiopharmaceuticals - chemistry Radiopharmaceuticals - metabolism Research Article Stilbenes - chemistry Stilbenes - metabolism Thiazoles - chemistry Thiazoles - metabolism
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