Preclinical Comparison of the Amyloid-β Radioligands [11C]Pittsburgh compound B and [18F]florbetaben in Aged APPPS1-21 and BRI1-42 Mouse Models of Cerebral Amyloidosis

Purpose The aim of this study was to compare [ 11 C]Pittsburgh compound B ([ 11 C]PiB) and [ 18 F]florbetaben ([ 18 F]FBB) for preclinical investigations of amyloid-β pathology. Procedures We investigated two aged animal models of cerebral amyloidosis with contrasting levels of amyloid-β relating to...

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Veröffentlicht in:Molecular imaging and biology 2015-10, Vol.17 (5), p.688-696
Hauptverfasser: Waldron, Ann-Marie, Verhaeghe, Jeroen, wyffels, Leonie, Schmidt, Mark, Langlois, Xavier, Van Der Linden, Annemie, Stroobants, Sigrid, Staelens, Steven
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Sprache:eng
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Zusammenfassung:Purpose The aim of this study was to compare [ 11 C]Pittsburgh compound B ([ 11 C]PiB) and [ 18 F]florbetaben ([ 18 F]FBB) for preclinical investigations of amyloid-β pathology. Procedures We investigated two aged animal models of cerebral amyloidosis with contrasting levels of amyloid-β relating to “high” (APPPS1-21 n  = 6, wild type (WT) n  = 7) and “low” (BRI1-42 n  = 6, WT n  = 6) target states, respectively. Results APPPS1-21 mice ( high target state ) demonstrated extensive fibrillar amyloid-β deposition that translated to significantly increased retention of [ 11 C]PiB and [ 18 F]FBB in comparison to their wild type. The retention pattern of [ 11 C]PiB and [ 18 F]FBB in this cohort displayed a significant correlation. However, the relative difference in tracer uptake between diseased and healthy mice was substantially higher for [ 11 C]PiB than for [ 18 F]FBB. Although immunohistochemistry confirmed the high plaque load in APPPS1-21 mice, correlation between tracer uptake and ex vivo quantification of amyloid-β was poor for both tracers. BRI1-42 mice ( low target state ) did not demonstrate increased tracer uptake. Conclusions In cases of high fibrillar amyloid-β burden, both tracers detected significant differences between diseased and healthy mice, with [ 11 C]PiB showing a larger dynamic range.
ISSN:1536-1632
1860-2002
DOI:10.1007/s11307-015-0833-9