miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer

Although surgery remains the mainstay of curative treatment for colorectal cancer (CRC), many patients still have high chance to experience disease relapse. It is therefore imperative to identify prognostic markers that can help predict the clinical outcomes of CRC. Aberrant microRNA expression hold...

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Veröffentlicht in:	Oncogene 2015-07, Vol.34 (31), p.4142-4152
Hauptverfasser:	Gao, J, Li, N, Dong, Y, Li, S, Xu, L, Li, X, Li, Y, Li, Z, Ng, S S, Sung, J J, Shen, L, Yu, J
Format:	Artikel
Sprache:	eng
Schlagworte:	13/2 13/31 13/51 38/77 631/67/1857 64/60 96/106 Adult Aged Aged, 80 and over Analysis Animals Apoptosis Biomarkers Biomarkers, Tumor - physiology Cell adhesion & migration Cell Biology Cell cycle Cell growth Cell migration Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Diagnosis Diseases Ectopic expression Female G1 phase Genes, p53 - physiology Genes, Tumor Suppressor - physiology Genetic aspects HCT116 Cells Health aspects Human Genetics Humans Internal Medicine Male Medicine Medicine & Public Health Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude MicroRNAs MicroRNAs - physiology Middle Aged miRNA Multivariate analysis Neoplasm Metastasis Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - genetics Neoplasm Staging Oncology original-article p53 Protein Patients Prognosis Protein expression Relapse Surgery Transcription Tumor proteins Tumors Xenografts
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Zusammenfassung:	Although surgery remains the mainstay of curative treatment for colorectal cancer (CRC), many patients still have high chance to experience disease relapse. It is therefore imperative to identify prognostic markers that can help predict the clinical outcomes of CRC. Aberrant microRNA expression holds great potential as diagnostic and prognostic biomarker for CRC. Here we aimed to investigate clinical potential of miR-34a-5p as a prognostic marker for CRC recurrence and its functional significance. First, we validated that miR-34a-5p was downregulated in CRC tumour tissues ( P
ISSN:	0950-9232 1476-5594
DOI:	10.1038/onc.2014.348