Efficacy of Inactivated Photobacterium damselae subsp. piscicida Combined with Levan/Alum as Vaccine against Photobacteriosis in Cobia, Rachycentron canadum
Photobacterium damselae subsp. piscicida (Phdp) is a major pathogen of cultured cobia (Rachycentron canadum), a primary target species for offshore cage culture in Taiwan. Serum antibody titers as well as efficiency and duration of protection against Phdp were evaluated following intraperitoneal adm...
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| Veröffentlicht in: | Journal of the World Aquaculture Society 2015-10, Vol.46 (5), p.549-556 |
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| container_title | Journal of the World Aquaculture Society |
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| creator | Guo, Jiin‐Ju Huang, Mei‐Ying Hong, Jia‐Wei Chuang, Ya‐Chu Chou, Ruey‐Ling Lee, Yan‐Horn Chen, Tzyy‐Ing |
| description | Photobacterium damselae subsp. piscicida (Phdp) is a major pathogen of cultured cobia (Rachycentron canadum), a primary target species for offshore cage culture in Taiwan. Serum antibody titers as well as efficiency and duration of protection against Phdp were evaluated following intraperitoneal administration of a candidate vaccine prepared with formalin‐inactivated whole cells in combination with levan/alum adjuvants. The results showed vaccinates delayed the disease onset and had significantly (P |
| doi_str_mv | 10.1111/jwas.12216 |
| format | Article |
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Serum antibody titers as well as efficiency and duration of protection against Phdp were evaluated following intraperitoneal administration of a candidate vaccine prepared with formalin‐inactivated whole cells in combination with levan/alum adjuvants. The results showed vaccinates delayed the disease onset and had significantly (P < 0.05) less mortality than control nonvaccinates during Days 21–105 postvaccination with highest relative percentage of survival (RPS) and antibody titer up to 81.4% and 1:614, respectively. There was a highly significant positive linear correlation between the RPS and antibody titer (R² = 0.841). Long‐lasting and significant protection against Phdp can be achieved with inactivated Phdp plus levan/alum, a potential cobia vaccine against photobacteriosis. Levan/alum complex may represent a promising adjuvant formula for the development of a Phdp vaccine.</description><identifier>ISSN: 0893-8849</identifier><identifier>EISSN: 1749-7345</identifier><identifier>DOI: 10.1111/jwas.12216</identifier><language>eng</language><publisher>Hoboken, USA: Wiley Subscription Services, Inc</publisher><subject>adjuvants ; alum ; antibodies ; blood serum ; cage culture ; intraperitoneal injection ; levan ; Marine ; mortality ; pathogens ; Photobacterium damselae ; Photobacterium damselae subsp. piscicida ; Rachycentron canadum ; Rodents ; Vaccines</subject><ispartof>Journal of the World Aquaculture Society, 2015-10, Vol.46 (5), p.549-556</ispartof><rights>Copyright by the World Aquaculture Society 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3966-9ec6f44e1915cf7a8ff2a93afbe5946b8472accc155106b337dedf458bfdc14f3</citedby><cites>FETCH-LOGICAL-c3966-9ec6f44e1915cf7a8ff2a93afbe5946b8472accc155106b337dedf458bfdc14f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjwas.12216$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjwas.12216$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids></links><search><creatorcontrib>Guo, Jiin‐Ju</creatorcontrib><creatorcontrib>Huang, Mei‐Ying</creatorcontrib><creatorcontrib>Hong, Jia‐Wei</creatorcontrib><creatorcontrib>Chuang, Ya‐Chu</creatorcontrib><creatorcontrib>Chou, Ruey‐Ling</creatorcontrib><creatorcontrib>Lee, Yan‐Horn</creatorcontrib><creatorcontrib>Chen, Tzyy‐Ing</creatorcontrib><title>Efficacy of Inactivated Photobacterium damselae subsp. piscicida Combined with Levan/Alum as Vaccine against Photobacteriosis in Cobia, Rachycentron canadum</title><title>Journal of the World Aquaculture Society</title><addtitle>J World Aquacult Soc</addtitle><description>Photobacterium damselae subsp. piscicida (Phdp) is a major pathogen of cultured cobia (Rachycentron canadum), a primary target species for offshore cage culture in Taiwan. Serum antibody titers as well as efficiency and duration of protection against Phdp were evaluated following intraperitoneal administration of a candidate vaccine prepared with formalin‐inactivated whole cells in combination with levan/alum adjuvants. The results showed vaccinates delayed the disease onset and had significantly (P < 0.05) less mortality than control nonvaccinates during Days 21–105 postvaccination with highest relative percentage of survival (RPS) and antibody titer up to 81.4% and 1:614, respectively. There was a highly significant positive linear correlation between the RPS and antibody titer (R² = 0.841). Long‐lasting and significant protection against Phdp can be achieved with inactivated Phdp plus levan/alum, a potential cobia vaccine against photobacteriosis. Levan/alum complex may represent a promising adjuvant formula for the development of a Phdp vaccine.</description><subject>adjuvants</subject><subject>alum</subject><subject>antibodies</subject><subject>blood serum</subject><subject>cage culture</subject><subject>intraperitoneal injection</subject><subject>levan</subject><subject>Marine</subject><subject>mortality</subject><subject>pathogens</subject><subject>Photobacterium damselae</subject><subject>Photobacterium damselae subsp. piscicida</subject><subject>Rachycentron canadum</subject><subject>Rodents</subject><subject>Vaccines</subject><issn>0893-8849</issn><issn>1749-7345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kcFuEzEQhlcIJELhwgtgiQtCbGqv7fX6GEUlFEUFUUolLtas124cdu1g7zbkXXhYXAJIcMAXy_L3jWbmL4qnBM9JPqfbPaQ5qSpS3ytmRDBZCsr4_WKGG0nLpmHyYfEopS3GFee8nhXfz6x1GvQBBYvOPejR3cJoOvR-E8bQ5reJbhpQB0MyPRiUpjbt5mjnknbadYCWYWidz8bejRu0NrfgTxd9ViChT6B1_kNwA86n8a-iIbmEnM9-6-AV-gB6c9DGjzF4pMFDNw2PiwcW-mSe_LpPiqvXZx-Xb8r1u9X5crEuNZV1XUqja8uYIZJwbQU01lYgKdjWcMnqtmGiyo1owjnBdUup6ExnGW9a22nCLD0pXhzr7mL4Opk0qiGPZ_oevAlTUkTkjQpMRJ3R5_-g2zBFn7vLFGm4pHn3mXp5pHQMKUVj1S66AeJBEazuglJ3QamfQWWYHOG9683hP6R6e724_O2UR8el0Xz740D8ompBBVfXFyslyEpefJZcVZl_duQtBAU30SV1dVlhUmOMm4YwTH8AyM2www</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Guo, Jiin‐Ju</creator><creator>Huang, Mei‐Ying</creator><creator>Hong, Jia‐Wei</creator><creator>Chuang, Ya‐Chu</creator><creator>Chou, Ruey‐Ling</creator><creator>Lee, Yan‐Horn</creator><creator>Chen, Tzyy‐Ing</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley & Sons, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TN</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H94</scope><scope>H95</scope><scope>H98</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>201510</creationdate><title>Efficacy of Inactivated Photobacterium damselae subsp. piscicida Combined with Levan/Alum as Vaccine against Photobacteriosis in Cobia, Rachycentron canadum</title><author>Guo, Jiin‐Ju ; 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Serum antibody titers as well as efficiency and duration of protection against Phdp were evaluated following intraperitoneal administration of a candidate vaccine prepared with formalin‐inactivated whole cells in combination with levan/alum adjuvants. The results showed vaccinates delayed the disease onset and had significantly (P < 0.05) less mortality than control nonvaccinates during Days 21–105 postvaccination with highest relative percentage of survival (RPS) and antibody titer up to 81.4% and 1:614, respectively. There was a highly significant positive linear correlation between the RPS and antibody titer (R² = 0.841). Long‐lasting and significant protection against Phdp can be achieved with inactivated Phdp plus levan/alum, a potential cobia vaccine against photobacteriosis. Levan/alum complex may represent a promising adjuvant formula for the development of a Phdp vaccine.</abstract><cop>Hoboken, USA</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/jwas.12216</doi><tpages>8</tpages></addata></record> |
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| subjects | adjuvants alum antibodies blood serum cage culture intraperitoneal injection levan Marine mortality pathogens Photobacterium damselae Photobacterium damselae subsp. piscicida Rachycentron canadum Rodents Vaccines |
| title | Efficacy of Inactivated Photobacterium damselae subsp. piscicida Combined with Levan/Alum as Vaccine against Photobacteriosis in Cobia, Rachycentron canadum |
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