Antibodies Prepared to Neuronal Glutamate Receptor Subunit3 Bind IFNα-Receptors: Implications for an Autoimmune Process
Anti-glutamate receptor (GluR) agonist-like antibodies prepared in rabbits that are similar to autoantibodies found in Rasmussen's encephalitis (RE) were found to exhibit greater immunoreactivity towards human interferon alpha receptor (IFNAR-1) than to GluR3. Since antibodies prepared to a def...
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| Veröffentlicht in: | Autoimmunity (Chur, Switzerland) Switzerland), 1998-01, Vol.28 (4), p.243-248 |
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| container_title | Autoimmunity (Chur, Switzerland) |
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| creator | Gahring, L. C. Carlson, N. G. Rogers, S. W. |
| description | Anti-glutamate receptor (GluR) agonist-like antibodies prepared in rabbits that are similar to autoantibodies found in Rasmussen's encephalitis (RE) were found to exhibit greater immunoreactivity towards human interferon alpha receptor (IFNAR-1) than to GluR3. Since antibodies prepared to a defined region of GluR3 can react preferentially to an unrelated sequence in the human IFNAR-1, we propose that the IFNAR-1 may be an heteroclitic antigen of GluR3. These results suggest that differential reactivity toward heteroclitic antigens may contribute to variable clinical characteristics of certain autoimmune diseases. |
| doi_str_mv | 10.3109/08916939808995372 |
| format | Article |
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These results suggest that differential reactivity toward heteroclitic antigens may contribute to variable clinical characteristics of certain autoimmune diseases.</description><identifier>ISSN: 0891-6934</identifier><identifier>EISSN: 1607-842X</identifier><identifier>DOI: 10.3109/08916939808995372</identifier><language>eng</language><publisher>Abingdon: Informa UK Ltd</publisher><subject>Antibodies ; Biological and medical sciences ; Epitope ; Glutamate ; Heteroclicity ; Interferon ; Medical sciences ; Nervous system involvement in other diseases. 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These results suggest that differential reactivity toward heteroclitic antigens may contribute to variable clinical characteristics of certain autoimmune diseases.</description><subject>Antibodies</subject><subject>Biological and medical sciences</subject><subject>Epitope</subject><subject>Glutamate</subject><subject>Heteroclicity</subject><subject>Interferon</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. 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Miscellaneous</topic><topic>Neurology</topic><topic>Receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gahring, L. C.</creatorcontrib><creatorcontrib>Carlson, N. G.</creatorcontrib><creatorcontrib>Rogers, S. W.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Autoimmunity (Chur, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gahring, L. C.</au><au>Carlson, N. G.</au><au>Rogers, S. 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These results suggest that differential reactivity toward heteroclitic antigens may contribute to variable clinical characteristics of certain autoimmune diseases.</abstract><cop>Abingdon</cop><pub>Informa UK Ltd</pub><doi>10.3109/08916939808995372</doi><tpages>6</tpages></addata></record> |
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| ispartof | Autoimmunity (Chur, Switzerland), 1998-01, Vol.28 (4), p.243-248 |
| issn | 0891-6934 1607-842X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17218391 |
| source | Taylor & Francis:Master (3349 titles) |
| subjects | Antibodies Biological and medical sciences Epitope Glutamate Heteroclicity Interferon Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Receptors |
| title | Antibodies Prepared to Neuronal Glutamate Receptor Subunit3 Bind IFNα-Receptors: Implications for an Autoimmune Process |
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