Antibodies Prepared to Neuronal Glutamate Receptor Subunit3 Bind IFNα-Receptors: Implications for an Autoimmune Process

Anti-glutamate receptor (GluR) agonist-like antibodies prepared in rabbits that are similar to autoantibodies found in Rasmussen's encephalitis (RE) were found to exhibit greater immunoreactivity towards human interferon alpha receptor (IFNAR-1) than to GluR3. Since antibodies prepared to a def...

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Veröffentlicht in:Autoimmunity (Chur, Switzerland) Switzerland), 1998-01, Vol.28 (4), p.243-248
Hauptverfasser: Gahring, L. C., Carlson, N. G., Rogers, S. W.
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Sprache:eng
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Zusammenfassung:Anti-glutamate receptor (GluR) agonist-like antibodies prepared in rabbits that are similar to autoantibodies found in Rasmussen's encephalitis (RE) were found to exhibit greater immunoreactivity towards human interferon alpha receptor (IFNAR-1) than to GluR3. Since antibodies prepared to a defined region of GluR3 can react preferentially to an unrelated sequence in the human IFNAR-1, we propose that the IFNAR-1 may be an heteroclitic antigen of GluR3. These results suggest that differential reactivity toward heteroclitic antigens may contribute to variable clinical characteristics of certain autoimmune diseases.
ISSN:0891-6934
1607-842X
DOI:10.3109/08916939808995372