Diaryl substituted pyrrolidinones and pyrrolones as 5-HT sub(2C) inhibitors: Synthesis and biological evaluation

Diaryl substituted pyrrolidinones and pyrrolones as 5-HT sub(2C) inhibitors: Synthesis and biological evaluation

Within the continuous quest for the discovery of novel compounds able to treat anxiety and depression, the generation of a pharmacophore model for 5- HT sub(2C) receptor antagonists and the discovery of a new class of potent and selective 5-HT sub(2C) molecules are reported.

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2006-01, Vol.16 (15), p.3906-3912
Hauptverfasser: Micheli, Fabrizio, Pasquarello, Alessandra, Tedesco, Giovanna, Hamprecht, Dieter, Bonanomi, Giorgio, Checchia, Anna, Jaxa-Chamiec, Albert, Damiani, Federica, Davalli, Silvia, Donati, Daniele, Gallotti, Chiara, Petrone, Marcella, Rinaldi, Marilisa, Riley, Graham, Terreni, Silvia, Wood, Martyn
Format: Artikel
Sprache:eng
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Zusammenfassung:Within the continuous quest for the discovery of novel compounds able to treat anxiety and depression, the generation of a pharmacophore model for 5- HT sub(2C) receptor antagonists and the discovery of a new class of potent and selective 5-HT sub(2C) molecules are reported.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.05.034