Effect of permeabilizers on antibiotic sensitivity of Pseudomonas aeruginosa
Agents which had previously been shown to act as permeabilizers against Pseudomonas aeruginosa or other Gram‐negative bacteria were tested to determine whether susceptibility to various antibiotics could be increased. In the absence of a permeabilizer, Ps. aeruginosa was resistant to several hydroph...
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| Veröffentlicht in: | Letters in applied microbiology 1999-01, Vol.28 (1), p.13-16 |
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| container_title | Letters in applied microbiology |
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| creator | Ayres, H. M. Furr, J. R. Russell, A. D. |
| description | Agents which had previously been shown to act as permeabilizers against Pseudomonas aeruginosa or other Gram‐negative bacteria were tested to determine whether susceptibility to various antibiotics could be increased. In the absence of a permeabilizer, Ps. aeruginosa was resistant to several hydrophobic antibiotics and vancomycin, but not to gentamicin. Tartaric and gluconic acids had weak potentiating activity, whereas ethylenediamine tetraacetic acid and citric acid were more effective permeabilizers. However, sodium polyphosphate enhanced the activity of erythromycin, fucidin, novobiocin, rifampicin and methicillin ; vancomycin was unaffected and the activity of gentamicin was reduced considerably. |
| doi_str_mv | 10.1046/j.1365-2672.1999.00486.x |
| format | Article |
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M.</creatorcontrib><creatorcontrib>Furr, J. R.</creatorcontrib><creatorcontrib>Russell, A. D.</creatorcontrib><title>Effect of permeabilizers on antibiotic sensitivity of Pseudomonas aeruginosa</title><title>Letters in applied microbiology</title><addtitle>Lett Appl Microbiol</addtitle><description>Agents which had previously been shown to act as permeabilizers against Pseudomonas aeruginosa or other Gram‐negative bacteria were tested to determine whether susceptibility to various antibiotics could be increased. In the absence of a permeabilizer, Ps. aeruginosa was resistant to several hydrophobic antibiotics and vancomycin, but not to gentamicin. Tartaric and gluconic acids had weak potentiating activity, whereas ethylenediamine tetraacetic acid and citric acid were more effective permeabilizers. However, sodium polyphosphate enhanced the activity of erythromycin, fucidin, novobiocin, rifampicin and methicillin ; vancomycin was unaffected and the activity of gentamicin was reduced considerably.</description><subject>Action of physical and chemical agents on bacteria</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane Permeability - drug effects</subject><subject>Citric Acid - pharmacology</subject><subject>Drug Synergism</subject><subject>Edetic Acid - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gluconates - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Polyphosphates - pharmacology</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Tartrates - pharmacology</subject><issn>0266-8254</issn><issn>1472-765X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1LxDAQhoMoun78BelBvLVOPtuCFxG_YEUPCt5C0iaSpW3WpFXXX2_rLujR08zhmXmHZxBKMGQYmDhbZJgKnhKRkwyXZZkBsEJkn1tohllO0lzwl200AyJEWhDO9tB-jAsAKDApd9EeBqAAhM_Q_MpaU_WJt8nShNYo7Rr3ZUJMfJeornfa-d5VSTRddL17d_1qYh-jGWrf-k7FRJkwvLrOR3WIdqxqojna1AP0fH31dHmbzh9u7i4v5mnFCBOp4FYBVzXVBOfU5EaM52hNLRdK5yUvLeCKEKtLxTQUBSUaK8J5rWsGlNb0AJ2u9y6DfxtM7GXrYmWaRnXGD1HinGCGMRvBYg1WwccYjJXL4FoVVhKDnEzKhZxMysmknEzKH5Pycxw93mQMujX1n8G1uhE42QAqVqqxQXWVi79cTsZPTNj5GvtwjVn9O1_OL-7Hhn4D7V2PCA</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Ayres, H. 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Psychology</topic><topic>Gluconates - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Polyphosphates - pharmacology</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Tartrates - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ayres, H. M.</creatorcontrib><creatorcontrib>Furr, J. R.</creatorcontrib><creatorcontrib>Russell, A. 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D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of permeabilizers on antibiotic sensitivity of Pseudomonas aeruginosa</atitle><jtitle>Letters in applied microbiology</jtitle><addtitle>Lett Appl Microbiol</addtitle><date>1999-01</date><risdate>1999</risdate><volume>28</volume><issue>1</issue><spage>13</spage><epage>16</epage><pages>13-16</pages><issn>0266-8254</issn><eissn>1472-765X</eissn><coden>LAMIE7</coden><abstract>Agents which had previously been shown to act as permeabilizers against Pseudomonas aeruginosa or other Gram‐negative bacteria were tested to determine whether susceptibility to various antibiotics could be increased. In the absence of a permeabilizer, Ps. aeruginosa was resistant to several hydrophobic antibiotics and vancomycin, but not to gentamicin. Tartaric and gluconic acids had weak potentiating activity, whereas ethylenediamine tetraacetic acid and citric acid were more effective permeabilizers. 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| ispartof | Letters in applied microbiology, 1999-01, Vol.28 (1), p.13-16 |
| issn | 0266-8254 1472-765X |
| language | eng |
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| source | Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Action of physical and chemical agents on bacteria Anti-Bacterial Agents - pharmacology Bacteriology Biological and medical sciences Cell Membrane Permeability - drug effects Citric Acid - pharmacology Drug Synergism Edetic Acid - pharmacology Fundamental and applied biological sciences. Psychology Gluconates - pharmacology Microbial Sensitivity Tests Microbiology Polyphosphates - pharmacology Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Tartrates - pharmacology |
| title | Effect of permeabilizers on antibiotic sensitivity of Pseudomonas aeruginosa |
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