Effect of permeabilizers on antibiotic sensitivity of Pseudomonas aeruginosa

Agents which had previously been shown to act as permeabilizers against Pseudomonas aeruginosa or other Gram‐negative bacteria were tested to determine whether susceptibility to various antibiotics could be increased. In the absence of a permeabilizer, Ps. aeruginosa was resistant to several hydroph...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Letters in applied microbiology 1999-01, Vol.28 (1), p.13-16
Hauptverfasser: Ayres, H. M., Furr, J. R., Russell, A. D.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Agents which had previously been shown to act as permeabilizers against Pseudomonas aeruginosa or other Gram‐negative bacteria were tested to determine whether susceptibility to various antibiotics could be increased. In the absence of a permeabilizer, Ps. aeruginosa was resistant to several hydrophobic antibiotics and vancomycin, but not to gentamicin. Tartaric and gluconic acids had weak potentiating activity, whereas ethylenediamine tetraacetic acid and citric acid were more effective permeabilizers. However, sodium polyphosphate enhanced the activity of erythromycin, fucidin, novobiocin, rifampicin and methicillin ; vancomycin was unaffected and the activity of gentamicin was reduced considerably.
ISSN:0266-8254
1472-765X
DOI:10.1046/j.1365-2672.1999.00486.x