Glucose-6-phosphate dehydrogenase expression is correlated with poor clinical prognosis in esophageal squamous cell carcinoma

Abstract Increasing evidence has demonstrated that glucose-6-phosphate dehydrogenase (G6PD), a key metabolic enzyme, participating in pentose phosphate pathway (PPP), is tightly associated with development and progression of a variety of tumors. Here, we reported expression of G6PD and its associati...

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Veröffentlicht in:	European journal of surgical oncology 2015-10, Vol.41 (10), p.1293-1299
Hauptverfasser:	Wang, Xin, Li, XiaoJuan, Zhang, XiaQing, Fan, RuiTai, Gu, Hao, Shi, YongGang, Liu, HongTao
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Disease Progression Esophageal Neoplasms - enzymology Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma Esophagus - metabolism Esophagus - pathology Female Gene Expression Regulation, Neoplastic Glucose-6-phosphate dehydrogenase Glucosephosphate Dehydrogenase - genetics Glucosephosphate Dehydrogenase - metabolism Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Lymph Nodes - pathology Lymphatic Metastasis Male Middle Aged Neoplasm Grading Neoplasm Staging Pentose phosphate pathway Prognosis Prognostic factor Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Surgery
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Zusammenfassung:	Abstract Increasing evidence has demonstrated that glucose-6-phosphate dehydrogenase (G6PD), a key metabolic enzyme, participating in pentose phosphate pathway (PPP), is tightly associated with development and progression of a variety of tumors. Here, we reported expression of G6PD and its association with the prognosis of the patients with esophageal squamous cell carcinoma (ESCC). The results revealed significantly elevated G6PD mRNA and protein expressions in ESCC tissues compared with normal tissues ( P
ISSN:	0748-7983 1532-2157
DOI:	10.1016/j.ejso.2015.08.155