Fine mapping of the myosin light chain kinase ( MYLK ) gene replicates the association with asthma in populations of Spanish descent

[...]neither the top hit observed in the current study nor its proxy (rs78442149) were tested for association in the GABRIEL (http://www.cng.fr/gabriel/results.html) or EVE consortia, the largest GWAS meta-analyses in asthma performed in Europeans8 and multiethnic groups.9 No other variants from 1KG...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2015-10, Vol.136 (4), p.1116-1118.e9
Hauptverfasser:	Acosta-Herrera, Marialbert, MSc, Pino-Yanes, Maria, PhD, Ma, Shwu-Fan, PhD, Barreto-Luis, Amalia, BS, Corrales, Almudena, CLT, Cumplido, José, MD, Pérez-Rodríguez, Eva, MD, Campo, Paloma, MD, PhD, Eng, Celeste, BS, García-Robaina, José Carlos, MD, PhD, Quintela, Inés, MSc, Villar, Jesús, MD, PhD, Blanca, Miguel, MD, PhD, Carracedo, Ángel, MD, PhD, Carrillo, Teresa, MD, PhD, Garcia, Joe G.N., MD, Torgerson, Dara G., PhD, Burchard, Esteban G., MD, MPH, Flores, Carlos, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Allergy and Immunology Asthma Asthma - epidemiology Asthma - genetics Calcium-Binding Proteins - genetics Chromosome Mapping - methods Consortia Female Genes Genetics Genomes Humans Male Myosin-Light-Chain Kinase - genetics Polymorphism, Single Nucleotide Population Smooth muscle Spain - epidemiology Studies
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Zusammenfassung:	[...]neither the top hit observed in the current study nor its proxy (rs78442149) were tested for association in the GABRIEL (http://www.cng.fr/gabriel/results.html) or EVE consortia, the largest GWAS meta-analyses in asthma performed in Europeans8 and multiethnic groups.9 No other variants from 1KGP are in moderate LD with those 2 SNPs (highest r2 = 0.25).
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2015.04.025