Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis

To investigate the role of telomerase in the multistep colorectal carcinogenesis, we examined telomerase activity in 31 adenomatous polyps and 22 paired cancer-normal mucosa specimens from non-hereditary nonpolyposis colorectal cancer patients. Telomerase activity was detected in 18% of normal mucos...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1998-09, Vol.58 (18), p.4052-4054
Hauptverfasser:	REIPING TANG, CHENG, A.-J, WANG, J.-Y, WANG, T.-C. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli - enzymology Adenomatous Polyposis Coli - pathology Analysis of Variance Biological and medical sciences Disease Progression Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Middle Aged Neoplasm Proteins - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Telomerase - metabolism Tumors
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Zusammenfassung:	To investigate the role of telomerase in the multistep colorectal carcinogenesis, we examined telomerase activity in 31 adenomatous polyps and 22 paired cancer-normal mucosa specimens from non-hereditary nonpolyposis colorectal cancer patients. Telomerase activity was detected in 18% of normal mucosa, 16% of small (2.0 cm) polyps, and 96% of adenocarcinoma samples (P for trend,
ISSN:	0008-5472 1538-7445