Synthesis of [allyl-2,3-3H]-MN-9201

Key step of the synthesis of calcium antagonist MN‐9201 was the cyclizing addition of the allyl‐3‐amino‐crotonate onto methyl 2‐[(3‐nitrophenyl) methylene]‐3‐oxobutanoate. It was then used to synthesize [Allyl‐2,3‐3H]‐MN‐9201 by the catalytic addition of tritium gas. Its radiochemical purity and spe...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 1998-09, Vol.41 (9), p.785-789
Hauptverfasser:	Wu, Dezhu, Huang, Wenlin, Wang, Wen, Mei, Qibing
Format:	Artikel
Sprache:	eng
Schlagworte:	3-3H]-MN-9201 [Allyl‐2,3‐3H]‐MN‐9201 Allyl-2 Biological and medical sciences Cardiovascular system Contrast media. Radiopharmaceuticals Medical sciences Miscellaneous MN-9201 Pharmacology. Drug treatments synthesis tritium addition
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Beschreibung
Zusammenfassung:	Key step of the synthesis of calcium antagonist MN‐9201 was the cyclizing addition of the allyl‐3‐amino‐crotonate onto methyl 2‐[(3‐nitrophenyl) methylene]‐3‐oxobutanoate. It was then used to synthesize [Allyl‐2,3‐3H]‐MN‐9201 by the catalytic addition of tritium gas. Its radiochemical purity and specific activity were 98% and 2.1 TBq/mmol, respectively. © 1998 John Wiley & Sons, Ltd.
ISSN:	0362-4803 1099-1344
DOI:	10.1002/(SICI)1099-1344(1998090)41:9<785::AID-JLCR133>3.0.CO;2-D