Ochratoxicosis: prevention of developmental toxicity by L-methionine in rats
l‐Methionine was found to inhibit the developmental toxicity induced by ochratoxin A (OA) in pregnant female rats. The fetuses had significantly lower weights. Dams and fetuses treated with OA had visceral and skeletal anomalies, while combined treatment with l‐methionine and OA showed no significan...
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| Veröffentlicht in: | Journal of applied toxicology 1999-01, Vol.19 (1), p.7-12 |
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| container_title | Journal of applied toxicology |
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| creator | Abdel-Wahhab, M. A. Nada, S. A. Arbid, M. S. |
| description | l‐Methionine was found to inhibit the developmental toxicity induced by ochratoxin A (OA) in pregnant female rats. The fetuses had significantly lower weights. Dams and fetuses treated with OA had visceral and skeletal anomalies, while combined treatment with l‐methionine and OA showed no significant changes when compared to the control. Histopathological examinations revealed that OA caused alterations in liver, kidney and vagina of pregnant rats, whereas methionine supplementation provided partial protection for renal and liver tissue. Copyright © 1998 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/(SICI)1099-1263(199901/02)19:1<7::AID-JAT529>3.0.CO;2-G |
| format | Article |
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A.</creatorcontrib><creatorcontrib>Nada, S. A.</creatorcontrib><creatorcontrib>Arbid, M. S.</creatorcontrib><title>Ochratoxicosis: prevention of developmental toxicity by L-methionine in rats</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>l‐Methionine was found to inhibit the developmental toxicity induced by ochratoxin A (OA) in pregnant female rats. The fetuses had significantly lower weights. Dams and fetuses treated with OA had visceral and skeletal anomalies, while combined treatment with l‐methionine and OA showed no significant changes when compared to the control. Histopathological examinations revealed that OA caused alterations in liver, kidney and vagina of pregnant rats, whereas methionine supplementation provided partial protection for renal and liver tissue. Copyright © 1998 John Wiley & Sons, Ltd.</description><subject>Abnormalities, Drug-Induced - prevention & control</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Bone and Bones - abnormalities</subject><subject>Drug Interactions</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fetus - drug effects</subject><subject>fetuses</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>L-methionine</subject><subject>Male</subject><subject>Methionine - pharmacology</subject><subject>ochratoxin A</subject><subject>Ochratoxins - toxicity</subject><subject>Pregnancy</subject><subject>protection</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Teratogens - toxicity</subject><subject>teratology</subject><subject>Teratology. Teratogens</subject><subject>Viscera - abnormalities</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1v0zAYhSMEGmXwE5BygdB2ke614_ijIFAJrHQq9IKhwdUrx3M0Qz5KnML673FJVC5A2pXl9zw-PvaJotcEpgSAnp18WubLUwJKJYTy9IQopYCcAT0lakZeitlsvnybXMwvM6pepVOY5usXNFnciyaHM_ejCVAOCUvFl4fRI--_AQSNyqPoSCmpmCCTaLU2N53u21tnWu_8LN509qdtetc2cVvG12FTtZs6THQV_8Fcv4uLXbxKatvfBMw1NnZNHEz84-hBqStvn4zrcfT5_N1l_j5ZrRfLfL5KDFNCJVyWIuOsMJIxQxjjkkOaGkYtNUqDLQxYwyAjpWQcOKhSFMTIQmpeqKzg6XH0fPDddO2PrfU91s4bW1W6se3WIxEURErZ3SDLIKNUBPBqAE3Xet_ZEjedq3W3QwK4LwRxXwjuPxf3n4tDIRgUEiYoEEMhOBSCKQLma6S4CM5PxwjborbXB9-xgaA_G3Xtja7KTjfG-b_Xc5VJJgP2dcB-ucru_kl3V7j_ZhsnwTsZvJ3v7e3BW3ffkYtUZHj1MbBZRs8_XLwJT_oNLnvCQg</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Abdel-Wahhab, M. A.</creator><creator>Nada, S. A.</creator><creator>Arbid, M. S.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope><scope>M7N</scope></search><sort><creationdate>199901</creationdate><title>Ochratoxicosis: prevention of developmental toxicity by L-methionine in rats</title><author>Abdel-Wahhab, M. A. ; Nada, S. A. ; Arbid, M. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4979-68f7564bc844c144686033c42e2c9a0ebc0ec4051f8460609f7b1c8b8a6b95b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Abnormalities, Drug-Induced - prevention & control</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Bone and Bones - abnormalities</topic><topic>Drug Interactions</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fetus - drug effects</topic><topic>fetuses</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>L-methionine</topic><topic>Male</topic><topic>Methionine - pharmacology</topic><topic>ochratoxin A</topic><topic>Ochratoxins - toxicity</topic><topic>Pregnancy</topic><topic>protection</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Teratogens - toxicity</topic><topic>teratology</topic><topic>Teratology. Teratogens</topic><topic>Viscera - abnormalities</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdel-Wahhab, M. A.</creatorcontrib><creatorcontrib>Nada, S. A.</creatorcontrib><creatorcontrib>Arbid, M. 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S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ochratoxicosis: prevention of developmental toxicity by L-methionine in rats</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>1999-01</date><risdate>1999</risdate><volume>19</volume><issue>1</issue><spage>7</spage><epage>12</epage><pages>7-12</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>l‐Methionine was found to inhibit the developmental toxicity induced by ochratoxin A (OA) in pregnant female rats. The fetuses had significantly lower weights. Dams and fetuses treated with OA had visceral and skeletal anomalies, while combined treatment with l‐methionine and OA showed no significant changes when compared to the control. 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| language | eng |
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| subjects | Abnormalities, Drug-Induced - prevention & control Animals Biological and medical sciences Body Weight - drug effects Bone and Bones - abnormalities Drug Interactions Embryology: invertebrates and vertebrates. Teratology Female Fetus - drug effects fetuses Fundamental and applied biological sciences. Psychology L-methionine Male Methionine - pharmacology ochratoxin A Ochratoxins - toxicity Pregnancy protection Random Allocation Rats Rats, Sprague-Dawley Teratogens - toxicity teratology Teratology. Teratogens Viscera - abnormalities |
| title | Ochratoxicosis: prevention of developmental toxicity by L-methionine in rats |
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