Ochratoxicosis: prevention of developmental toxicity by L-methionine in rats

l‐Methionine was found to inhibit the developmental toxicity induced by ochratoxin A (OA) in pregnant female rats. The fetuses had significantly lower weights. Dams and fetuses treated with OA had visceral and skeletal anomalies, while combined treatment with l‐methionine and OA showed no significan...

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Veröffentlicht in:	Journal of applied toxicology 1999-01, Vol.19 (1), p.7-12
Hauptverfasser:	Abdel-Wahhab, M. A., Nada, S. A., Arbid, M. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced - prevention & control Animals Biological and medical sciences Body Weight - drug effects Bone and Bones - abnormalities Drug Interactions Embryology: invertebrates and vertebrates. Teratology Female Fetus - drug effects fetuses Fundamental and applied biological sciences. Psychology L-methionine Male Methionine - pharmacology ochratoxin A Ochratoxins - toxicity Pregnancy protection Random Allocation Rats Rats, Sprague-Dawley Teratogens - toxicity teratology Teratology. Teratogens Viscera - abnormalities
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Beschreibung
Zusammenfassung:	l‐Methionine was found to inhibit the developmental toxicity induced by ochratoxin A (OA) in pregnant female rats. The fetuses had significantly lower weights. Dams and fetuses treated with OA had visceral and skeletal anomalies, while combined treatment with l‐methionine and OA showed no significant changes when compared to the control. Histopathological examinations revealed that OA caused alterations in liver, kidney and vagina of pregnant rats, whereas methionine supplementation provided partial protection for renal and liver tissue. Copyright © 1998 John Wiley & Sons, Ltd.
ISSN:	0260-437X 1099-1263
DOI:	10.1002/(SICI)1099-1263(199901/02)19:1<7::AID-JAT529>3.0.CO;2-G