Changes in Glucose Metabolism in Vertical Sleeve Gastrectomy

Changes in Glucose Metabolism in Vertical Sleeve Gastrectomy

Background We evaluated metabolic changes after vertical sleeve gastrectomy (VSG) surgery in a rat model using proteomics and metabolomic profiling in liver and serum. Methods Rats were randomly divided into two groups: sham ( n  = 10) and VSG ( n  = 12). Food intake, body weight, blood glucose, ins...

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Veröffentlicht in:Obesity surgery 2015-11, Vol.25 (11), p.2002-2010
Hauptverfasser: Lho, Yunmee, le Roux, Carel W., Park, Hyeon Soo, Kim, Gon Sup, Jung, Jeeyoun, Hwang, Geum-Sook, Seo, Youn Kyoung, Ha, Tae Kyung, Ha, Eunyoung
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Blood Glucose - metabolism
Diabetes
Disease Models, Animal
Eating - physiology
Enzymes
Gastrectomy - methods
Gastrointestinal surgery
Gluconeogenesis - physiology
Glucose
Glucose-6-Phosphatase - metabolism
Insulin - blood
Male
Medicine
Medicine & Public Health
Metabolism
Obesity, Morbid - metabolism
Obesity, Morbid - surgery
Original Contributions
Rats
Rats, Sprague-Dawley
Studies
Surgery
Weight Loss
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Zusammenfassung:Background We evaluated metabolic changes after vertical sleeve gastrectomy (VSG) surgery in a rat model using proteomics and metabolomic profiling in liver and serum. Methods Rats were randomly divided into two groups: sham ( n  = 10) and VSG ( n  = 12). Food intake, body weight, blood glucose, insulin, and thyroid hormone levels were measured. Two-dimensional electrophoresis, nuclear resonance spectroscopy, mass spectroscopy, immunofluorescence, and immunoblot analyses were used to determine and validate changes in metabolites and proteins in liver tissue and serum samples. Results Food intake and body weight decreased after VSG group ( p  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-015-1636-4